Taxanes are less effective in some patients with BRCA1 mutations, according to Dutch investigators.
If confirmed, the results "can have a major impact on the choice of type of (adjuvant) chemotherapy in BRCA1 mutation carriers with hormone receptor negative or triple negative breast cancer," said lead author Dr. Mieke Kriege in email to Reuters Health.
In a July 14th online paper in Cancer, Dr. Kriege and colleagues at Erasmus MC-Daniel den Hoed Cancer Center in Rotterdam note there is growing evidence from preclinical studies that sensitivity to taxanes requires a functional BRCA1 protein.....
If confirmed, the results "can have a major impact on the choice of type of (adjuvant) chemotherapy in BRCA1 mutation carriers with hormone receptor negative or triple negative breast cancer," said lead author Dr. Mieke Kriege in email to Reuters Health.
In a July 14th online paper in Cancer, Dr. Kriege and colleagues at Erasmus MC-Daniel den Hoed Cancer Center in Rotterdam note there is growing evidence from preclinical studies that sensitivity to taxanes requires a functional BRCA1 protein.....
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