21.08.11

Reducing Excessive Toxicity in Ovarian Cancer Treatment: Primary Chemotherapy

Reducing Excessive Toxicity in Ovarian Cancer Treatment: Primary Chemotherapy:


...here has been a lack of good evidence for the routine use of neuroprotective agents in the chemotherapy regimen, such as vitamin E, amifostine, amitriptyline, dimensa, gabapentin, glutamine and lamotrigine.[35] There are ongoing Phase II/III trials evaluating specific agents; however, at this time, the American Society of Clinical Oncology does not support their routine use.[34–36]

The treatment of neuropathic pain has several options, but again their use has not been validated by large, randomized controlled trials.
In small numbers of patients gabapentin 400 mg three-times daily and amitriptyline 10–50 mg have been shown to provide relief in severe neuropathic pain patients.[33,34]
Prednisone doses of 10 mg twice a day beginning 24 h after therapy for 5 days has demonstrated some improvement in chemotherapy-associated neuropathy.[33] A discussion with the patient on the lack of good data to support the use of such agents should occur prior to any trial of therapy.....


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